Over the past months I have read many informational articles concerning Sprycel and the effects on the body. One item that sticks in my mind, (cannot remember where I read this) Sprycel is in and out of the body in about 5 hours. I find this very interesting. I do not have the 'hot ear symptom' until the following day after taking the pill. I usually take the Sprycel around 5 p.m., so in theory the pill should be pretty much gone by the next morning, but I get that red ear thingy in early afternoon before I am ready to take another pill. I never had this symptom till I began the Sprycel, now it is less severe than it used to be on the 140 mg, but it does continue to exist. Did I read correctly, or does the drug only kill the leukemia cells around the 5 hour time frame and of course all other side effects are not considered in this period? I find this entire idea interesting, I do know some meds are in and out of the body quickly and others build up, one of my son's drugs is a slow build it may take a full 6 weeks to reach potential and just as long to completely exit the body if he would stop taking this drug. I am under the impression Sprycel is not a drug that builds in the system, it goes in, does the job and heads out. I have read you cannot take the anti-acid 2 hours before or after so the body can absorb the TKI, but after that it is ok. Lately I have been experiencing serious heartburn, today was horrible, I felt many times I had a concrete block sitting on my chest and the burn in my throat is horrid, even eating dinner was a struggle, I finally gave up but am still uncomfortable many hours later. Any thoughts on these subjects I would appreciate. Thanks! (Lots of issues, if I need to separate each one for clarity I will.