I've always had some problems with acid reflux, even before the CML. After starting Gleevec 400mg, it seemed to get worse at about the 6 month poiint. The doctor said I could take pepcid with the gleevec safely about 12 hours apart. So that is what I have been doing for about 2 months. I don't know how long I can take pepcid with the Gleevec. Does anyone have experience with this? I really probably need to be taking Nexium or something stronger, but they don't recommend. Any info on this is appreciated.