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Can not perform FISH test ??? Low blood cell count !!


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#1 Nora@CML

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Posted 25 February 2012 - 07:09 AM

Hi Sisters and Brothers,

Today I went to the hospital to receive my FISH test result, but the result was as following

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"This hematological blood specimen is very hypocellular (WBC 2.1) and found not suitable for FISH"

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Is this normal ?

Regards,



#2 pammartin

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Posted 25 February 2012 - 08:41 AM

Hi Nora,

Although I have no information, I am sure there are many on here that can explain what is going on with your results.  I would estimate by this afternoon you will have many replies with excellent information.  I hope you have a peaceful day.

Pam



#3 Trey

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Posted 25 February 2012 - 10:27 AM

It may have been a version of FISH that is more selective about cell sampling, such as Metaphase FISH or some other specialty FISH test.  The FISH test test looks for 200 - 500 (or more) WBCs that are capable of dividing, and Metaphase FISH is much more selective than Interphase FISH.  So although a sampling failure is rare, it can happen.

Was this from blood or from marrow?



#4 Nora@CML

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Posted 25 February 2012 - 11:17 AM

Thanks



#5 Nora@CML

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Posted 25 February 2012 - 11:18 AM

Thanks Trey for explaniation

it was form blood



#6 Trey

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Posted 25 February 2012 - 01:38 PM

This is more likely to occur in the blood than marrow.  The dividing WBCs will tend to remain in the marrow during myelosuppression (very low WBC).



#7 Tedsey

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Posted 25 February 2012 - 04:07 PM

This is somewhat related, I guess.  I hate to start another thread...  I was told once by a phlebotomist, when I asked her to use a butterfly needle for me, that the butterfly can break apart the blood cells.  Has anyone heard of this (Trey?)?  My regular phlebotomist always uses the thin needle on me because I am a "bleeder".   If true, would this have any impact on the accuracy of a CBC/PCR?  I am inclined to believe that this woman is mistaken.  Blood cells are very tiny.  I cannot imagine that a thinner needle could break them.

Teds



#8 Lizzybee

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Posted 25 February 2012 - 07:27 PM

Teds,  I don't know about a butterfly needle, but my onc's lab tech only uses pediatric needles for everyone, because cancer pts have so many draws and a lot of them are hard to stick after awhile.

Elizabeth



#9 Susan61

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Posted 25 February 2012 - 07:35 PM

Hi :  I never heard of that.  I have been getting my blood drawn through the front of my hand for 13 years, because they cannot find my veins in my arm.  When I was going through all the testing way back when they thought I would be getting a BMT, they used the butterfly in the front of my  hand for all my tests then too.  I do not think they are using a small needle on me.  IT  hurts like heck everytime I get it done.  I am going to ask her next time I go for my blood test.

Good Question.

Susan






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