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Are BMBs really necessary nor or is there a blood test that will show the same results?


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#1 Idahogal

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Posted 24 February 2012 - 10:05 PM

Can someone please tell me what blood test I could have in place of a BMB?? I am scheduled for another BMB Thursday. In reading this blog there seems to be some discussion about a blood test that would show what a BMB does. If this is the case I would love to not have the BMB. Can anyone help me find the information I need to take to my onc? Thanks



#2 Trey

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Posted 24 February 2012 - 10:15 PM

Most Oncs will do them every 6 months until CCyR (zero BMB or zero FISH) is attained.  After that they are probably not worth doing unless there is a significant loss of drug response.

http://community.lls.org/docs/DOC-1273



#3 Idahogal

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Posted 25 February 2012 - 12:33 AM

Thanks Trey for the info. That helps, I guess I better have the BMB. Hopefully this one won't be as painful.



#4 Happycat

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Posted 25 February 2012 - 12:54 PM

I only had one a dx, none since.  My onc said he can get what he needs from a peripheral blood test for monitoring.  I think he snuck a FISH test in on me at one point, and he's been doing PCRs.  (If they didn't do FISH, he must've used a PCR to decide I was CCyR.)  He's offered to let me have one if I really wanted it, which I declined.  I have a feeling if I lost response, though, or had a huge increase, he'd probably order one.  However, I am more than happy to skip them now while all is good!

Traci



#5 CallMeLucky

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Posted 25 February 2012 - 01:14 PM

The test you are referring to is a FISH test which can be done on either bone marrow or peripheral blood.  If you are looking for PH+ chromosome, I believe many doctors would agree that the a FISH on peripheral blood is sufficient.  However, there are other things looked for in bone marrow that you cannot find in blood.  They look at quality of bone marrow any other genetic abnormalities etc.  It depends a lot on your doctor and your case.  Some doctors want to do them more others less, some people need them more, others less.  So hard to say in your case.  If you are really not into it, then you should have the conversation with the doctor let them know you are not crazy about doing it again and ask them to walk through why you need it, specifically what are they looking for that they can't determine from  FISH test done on blood.  If your doctor is sensitive to your feelings he should have no problem discussing it with you.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#6 Idahogal

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Posted 25 February 2012 - 08:47 PM

Thanks to all for your response. This helps so much.



#7 Susan61

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Posted 25 February 2012 - 09:40 PM

Hi:  Every doctor is different.  I always felt that on initial diagnosis it should have been confirmed with a BMB, but I have seen new patients only get the PCR test from the very beginning.  I got a BMB when first diagnosed, and then again at 3 months they did another one.  Once I got to a Ccyr, then they just started doing the PCR test, and that is all I have had now since 2001 every 6 months.  If you have not gotten to a Ccyr yet then that is probably why your still getting the BMB.  The best thing to do is ask your doctor.

Susan






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