Posted 16 February 2012 - 03:35 PM
I hadn't previously heard about the increased polyps-possibility when on a TKI.
I was on Gleevec, and then on Sprycel, since dx in Oct. 2008 (currently on trial TKI cessation). My PCP had me do yearly fecal-blood card testing. For two years results were negative; last year it was positive. I had a colonoscopy in September 2011 and they found and removed two small polyps. Now I will have a colonoscopy every five years, in addition to continuing the yearly f-b card testing.
Message was edited by: ChrisC due to Trey and others clarifying there is NO evidence that TKIs increase polyp production. Thanks!
Be alert, but not overly concerned.
• Dx Oct. 22, 2008, WBC 459k, in ICU for 2 days + in hospital 1 week
• Leukapheresis for 1 week, to reduce WBC (wasn't given Hydroxyurea)
• Oct. 28, 2008: CML confirmed, start Gleevec 400mg
• Oct. 31, 2008: sent home when WBC reached 121k
• On/off, reduced dose Gleevec for 7 months
• April 2009: Started Sprycel 100mg
• Sept. 2009: PCRU 0.000
• Sept. 2011: after 2 years steady PCRU & taking Sprycel 100mg before bed, quit Sprycel (with permission)
• Currently: still steady PCRU, testing every 6 months 🤗
— Fatigue, hearing loss continue, alas, but I prefer to think it is all getting better!