I know there are a couple of you out there. I just had my onc visit today and I am once again PRCU, which makes it about a year now. I was only diagnosed a year and 3 months ago, so clearly the Sprycel is working fantastically for me. But Onc and I were discussing lowering the dosage, when it would be acceptable, etc.
Her initial take (and she IS a CML specialist) is that it is too soon. That in the previous studies with Gleevec, those that did the best with lowering or stopping the drug were those that were PCRU for 5 years or more. Since Sprycel is so new, and there are not that many of us on it (statistically), she is unaware of any studies to lower the dosage of it and test for relapses.
But I remember that a few of you that go to Dr. Mauro or Dr. Cortez are on less. Was that because of the difficulty of tolerance to the drug, or because they wanted to see if you did ok on less.....? My Onc is wonderful and asked me to ask around and then send her what I found out.