I had my second bmb on Jan 11 and just got my results today. I'm CCR!! Yay!!!!
Results of second BMB
Posted 03 February 2012 - 05:05 PM
Posted 03 February 2012 - 06:01 PM
Congrats! Domu mind me asking how long it took and on what drug? Can you stop the drugs now?
Posted 03 February 2012 - 07:54 PM
Posted 03 February 2012 - 11:04 PM
Yeah i honestly don't blame you either! So you are already PH- after 9 months? I guess that is what CCR means right?
Posted 04 February 2012 - 10:44 AM
Rissa congratulations!! That is great news! I am "patiently" waiting for the results of my 6 month PCR.
Posted 04 February 2012 - 09:56 PM
Posted 05 February 2012 - 06:28 AM
Well done awesome news!
Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).
Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14
Posted 05 February 2012 - 09:48 AM
Welcome to the group! I know it is a bit overwhelming to you now but MDA will help you understand more about CML. A couple of things to point out. We don't become Ph-, that would actually not be a good thing as there are instances of people who have CML without the Philly chromosome and our TKIs do not work for them.
There is no definitive point where we can stop taking our TKI drugs. There may be trials going on where people whose leukemic cells have been undetectable for several years are attempting to see what will happen if they stop but no absolute point in time yet where someone says, "Ok, you're cured you can stop now." There is no Remission in CML, only Response to our TKIs - for now.
The point in your favor is your youth! So many advances have been made and there are more to be made and you will benefit from them all!
So do your mourning, take your pill and get on with your life. I'm not being flippant here, everyone of us, young or old, has mourned our perceived loses when we were first diagnosed - it is our ability to move on that makes the difference.
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
Posted 05 February 2012 - 08:39 PM
There are different levels of Response to your TKI
Here is some info from Trey's Blog
Stages of CML "Response":
- Diagnosis: A zero response baseline from which to measure response to therapy
- Complete Hematological Response (CHR): The WBC and platelets return to normal ranges and the spleen shrinks back to normal size
- Complete Cytogenetic Response (CCR): Either a BMB or a FISH is negative, or 2 log reduction in PCR from diagnosis or lab baseline average
- Major Molecular Response (MMR): PCR shows a 3 log (1000-fold) reduction in leukemia from diagnosis levels or lab baseline average
- Complete Molecular Response (CMR): PCR is negative/undetectable (PCRU), so BCR-ABL transcripts are undetectable by PCR testing (leukemia levels too low to detect)
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