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What exactly is Tumor Lysis Syndrome?

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#1 donkatking


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Posted 21 January 2012 - 03:17 AM

I get my Tasigna through a specialty pharmacy and was reading about Tasigna and side effects--stuff like that anyway and they made note of Tumor Lysis Syndrome.  I guess it shows up in all forms of Leukemnia and I'd just like to get a laymans description of this.  Just a better understanding as I never heard of it till yesterday!

#2 hannibellemo


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Posted 21 January 2012 - 09:25 AM

Interesting question! I checked Wikipedia and here is what I found.  http://en.wikipedia....lysis_syndrome.




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#3 Trey


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Posted 21 January 2012 - 10:05 AM

It is a very high rate of leukemic cells dying off, which is a good thing.  It only happens for a few weeks after starting initial TKI drug treatment, and is the reason Allopurinol is presrcibed along with the TKI drug.  For those taking TKI drugs for more than a month, this is not an issue unless the WBC has gone way up again (over approx 50K).  It is simply in the Novartis drug info sheet for those just diagnosed and starting TKI drugs to suggest they also take Allopurinol.  So in your case it is not applicable since you have been taking Tasigna for quite a while. 

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