I have copied the link and your post, and pasted to my email, as well for future reference and further studies.
I have read thru your post and skimmed thru parts of the link. I am trying to digest it, but am going to have to meditate on this for awhile and let it nest in my brain.
I tried to post it, more as a question, to explain what my understanding is, for correction, and fill in the blanks or put the puzzle together in a broader sense.
I will be studying it in more depth, (as time permits) as you said as an academic exercise!!
I guess one particular thing that has stumped me, which I think I understand in part, was this question in my mind; (background info) When I went for an annual check up, (2005) my platelets came back 1 million, (white cell 13 thousand) two week later, the platelets were at 2 million (white cells at 21 thousand). At this point I was not diagnosed and I was googling high platelets, and never suspecting leukemia. When I went to the oncologist to have another blood draw, I was thinking that someone didn't know how to read zero's, as my primary doctor said that she had gotten a call from the lab, that my platelets were only 1000. So my primary doctor called the pathologist (who is her husband) to check on the platelet count. The platelets were not 1 thousand, they were over a million, and climbing, (now 2 week later at over 2 million).
I went to the oncologist (at the cancer center) he was trying to explain, he wanted to do a BMB, as he was sure he was looking at a blood cancer. I was so confused because I knew leukemia was white cells, well I had over 2 million platelets. He kept explaining my granuloyctes were off, which makes up the white cells. Thus I have been trying to figure out the question why high platelets, and where are these chromosomes, platelets are not nucleus? ??
(The chromosomes are located in the cell's nucleus)
Your post helped me to somewhat understand ""It starts with a translocation in the chromosomes of a blood making (hematopoietic) stem cell very high in the chain. The chromosomes are located in the cell's nucleus, and are made up of numerous genes, which are the genetic blueprints for making the cells in the body."
But I am still having a little bit of trouble understanding the high platelets as they are not nucleus. I will reread the article and carefully read the link.
I am waiting for an insurance approval that they will be paying for the new Oncologist, as I have mailed a dispute into the insurance company, regarding the coding on my first visit to the new onc. I have gotten an Ok, from the doctors billing that they have approval from my insurance to use a certain code, to pay for the visit. It is kind of complicated, as insurance can be. But I want it in writing, so I am waiting the insurance has 60 days to answer me.
My new oncologist is with a group of leukemia experts, at the number 1 premier of Indiana. So when I go for my next visit, I don't want to go in asking dumb question or taking up valuable time, of things I can learn on my own. I imagine they get tired of explaining the same thing over and over, especially like you said of an academic nature.
Also I guess I sort started an interest in learning the academic dynamic of all the leukemias. Not sure why?
I know I was diagnosed in 2005 and just learned the basics of CML, and wanted to forget that I had cancer, except for taking that pill and of course the 3 month onc visits and labs. Then the question came up of changing drugs, which sent me back to getting myself up to date and the TKI and then that led me to thinking of other things and re educated myself.
I guess there was a lot I didn't learn on the first go around.
Anyhow I will certainly be digging into more articles and reading these post, until I get it!
Thank You again for taking the time to help me and also to Matt.