New Member
Posted 07 January 2012 - 02:54 PM
Hi Everyone. I have a few questions regarding neutrophils. First of all are neuts the same thing as polys? What does absoulte polys mean and what does it mean if your polys are in the normal range but your absolute polys are high? My ABS Polys are 35.13 the range is 2.0-6.4. Thanks in advance.
Judy
Advanced Member
Posted 07 January 2012 - 04:31 PM
The full name for a neutrophil is polymorphonuclear neutrophil. So polys are another name for neutrophils, and some labs use the "Poly" terminology. The neutrophils in the bloodstream are normally the more mature types, which are segs ("worker bee" mature neutrophils) and bands (which divide one more time and form segs). So the polys are typically segs and bands. "Abs Polys" and "ANC" are the same thing, and as the name implies is an absolute count per volume of blood. But when the lab report just says "Polys" it is a percentage related to all other WBCs (Lymphocytes, Basophils, Eosinophils, etc).
So your Abs Polys/ANC are quite high, and this is a concern 7 months post diagnosis. They will be very high at CML diagnosis, but should drop rapidly down to normal range after several weeks of TKI drug therapy (and you previously said you were CHR at one point). You also previously said you were off TKI drugs in December, and I believe you have now been on all three TKI drugs over the past 7 months. You reported that your WBC had risen significantly to over 50K recently, and that you have a new Onc. If the Sprycel does not work quickly to bring down WBC and FISH/PCR, then you need to see a specialist. I don't know if you had a Kinase Mutation Test done, but it would be a very good idea. You should be monitored closely.
New Member
Posted 07 January 2012 - 04:54 PM
Hi Trey,
Thanks for your reply. I feel like you have my medical records, its great!!! I am seeing a CML specialist now, my last wbc was down to 11,000 and I don't have my abs polys from last week, the ones I posted were from the week before. I will be starting Sprycel in 1½ weeks, never tried it before. My new onc. said he would have switched my medicine in Sept when my PCR test came back high if I had been seeing him then. I have tons of confidence in my new onc, he's at a leading cancer hospital with tons of experience in CML.. If Sprycel doesn't work at 50mg I will have to go up to 100mg. If that doesn't work I will then have to try Gleevec again at 300 mg per day. The problem for me is that I have kidney damage from another condition and also angioedema. My new onc. has run mutation testing, results should be back in another week or so, but since my wbc is responding I think he feels I probably don't have one. Hopefully I will respond to the Sprycel and will be able to tolerate the side effects. Also, my PCR test is down to 41% from 55%. I'm seeing my onc. again in 2 weeks. He's following me closely, getting tons of support on many levels at my new hospital.
Trey, you are terrific. Thank you for your concern.
Judy
Advanced Member
Posted 07 January 2012 - 05:37 PM
Judy, I'm glad you are happy with your new onc - it's just so important that we trust them isn't it.
I hope Sprycel brings you more success!
Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).
Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14
Advanced Member
Posted 07 January 2012 - 07:59 PM
The facts that your WBC had since returned to near normal and the Abs Poly results were outdated might have been relevant info to add.
New Member
Posted 07 January 2012 - 08:08 PM
Sorry Trey, I'm so ashamed.
Judy
Also, my blood work from last summer shows that even when my wbc was normal my neuts, not abs neuts, but neuts were always high. I'm thinking this may be because I don't have any B cells because I get Rituxin injections for another condition. So I'm thinking if there are no B cells then my % of neuts would be higher. I may not be making any sense, I'm not sure how everything correlates.
0 members, 1 guests, 0 anonymous users
