I am a 4+ yr CML patient, posting here for the first time. I transferred from gleevec to tasigna about 2 years ago due to moderate side effects on gleevec and lack of complete efficacy (I did not attain MMR). My PCR value has remained lowish (2.5-3 log reduction) since about 18 months into treatment, but has never been undetectable. I had a transient PCR increase in a single assessment about a year ago. I just had another increase (from ~3 log to ~2.7 log reduction) at my last test. All recent tests were performed on the same instrument and quantified in the same fashion, as far as I can tell.
My onc wants to retest in 6 weeks. I wonder how concerned I should be? Should I get mutation testing? Agitate for a switch to Sprycel? Has anyone else experienced transient PCR fluctuations in patients after years of therapy, or is this general indicative of resistance? I have heard anecdotes of PCRs wavering around PCRU, but in my case the level is somewhat higher.