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PCRU after only 3 months on Gleevec

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#1 saiyogo


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Posted 31 October 2011 - 06:58 AM

Well, I just returned from an appoinment with my Onc earlier today. Both of us were supprised to see the lab result (which was taken 3 week earlier), both the FISH and the PCR results are negative.

This is only my first PCR/FISH test after dx in June. I didn't expect it at all because from what I was reading around here Gleevec is a slower med and I need to be patience.

Although the Onc was quite happy, even suggested me to celebrate, I still have some question lingered:

1. Is this normal to be PCRU that early, 3 months ago my WBC is 49k and both the FISH and PCR were positive (they didn't tell me the exact number). Could it happen that I was misdx or something.

2. Does this mean I can start counting today and hope for a chance to reduce my dose like Trey and some other. Though not very awlful, the med made me quite tired sometime.

3. My metabolic test shown a slightly elevated creatinine, so what does it mean and what to do about it?

And good day everyone, though rarely posted, I read the board almost everday

Love all of you

#2 grannyd


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Posted 31 October 2011 - 07:18 AM

Congrats on your good report!!  Always good to read about good reports!!!

#3 LivingWellWithCML


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Posted 31 October 2011 - 09:01 AM

Wow, that is incredible news --- definitely much faster response than the norm.  Congratulations!

What dosage are you on?  400mg?

Dan - Atlanta, GA

CML CP Diagnosed March 2011

Gleevec 400mg

#4 CMLSurvivor


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Posted 31 October 2011 - 10:52 AM

That is great news!!! I do not think it is all that unusual to have PCRU at three months. You were diagnosed pretty early at 49K.  I obtained PCRU within 5 months and was diagnosed at 52K which is also pretty early. My doctor did not reduce my doseing until I maintained my PCRU for at least 3 years and only because the side effects were truely a bother. I barely could get away from the bathroom if you know what I mean.  Keep the faith! You are doing wonderful!

#5 Susan61


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Posted 31 October 2011 - 04:06 PM

Congratulations!!!!  I do know somebody who got to PCRU in 3 months. I was very surprised, and she is still doing very well.  She does not join the group here, but I keep trying to encourage her to do so to share her great experience.  The creatnine can be off for many reasons.  You can have a abnormal kidney function just from being dehydrated, and then it can go back to normal the next month.  I do not drink enough water, and my doctor keeps telling me to hydrate myself.  I am sure it has no connection to your Gleevec. 


#6 Trey


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Posted 31 October 2011 - 05:17 PM

The lower the WBC at diagnosis, the faster the response can be (but not always will be).

Creatinine issue:


#7 Pin


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Posted 31 October 2011 - 06:36 PM

Hey Xuân Nam, that's awesome news! Congratulations - I hope you are feeling much better with these results :) How is your work going?  Cheers, Pin.

Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).

Commenced monthly testing when MR4.0 lost during 2012.


2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)

2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)

2015: <0.01, <0.01, <0.01, 0.013

2014: PCRU, <0.01, <0.01, <0.01, <0.01

2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01 

2012: <0.01, <0.01, 0.013, 0.032, 0.021

2011: 38.00, 12.00, 0.14

#8 Marnie


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Posted 31 October 2011 - 06:49 PM



#9 Guest_billronm_*

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Posted 31 October 2011 - 07:58 PM

Hi Saiyogo,

   Congratulations you are doing great. Three months inspires all the new people on our site.I can't believe how many people have been joining I thought cml affected more middle aged people like me.(I'm not going to say old yet). But all you young people getting it doesn't make sense.  How are your parents doing? I remember they were having a pretty hard time accepting your dx. I can't even imagine how they felt your thier child. Sorry kiddo to us parents you'll always be our babies. There is so much research and a couple new meds coming out I just feel we are so close to a cure. Let them know that.

   Thanks for checking in with us and telling us your good news. I hope school is going okay for you.  best wishes Billie

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