I have cml -- and was diagnosed in September 2010 (so I am about 13 months post diagnosis)
I have two questions:
(1) At six months after diagnosis, PCR showed a "log decrease from the median ratio of 2.0" and said that "log change from my previous result is 1.6" -- the ratio BCR/ABL1 to ABL1: 0.09196 (which I understand shows better than expected decrease of bad cells)
I am confused that when reading online about PCR test results and log decreases -which figure (median or individual) is the one referred to when people talk about the log reduction progress
(2) At one year, my PCR results revealed a "statistically significant" difference from 6 month findings but in undesired direction (meaning that the amount of bad cells detected did not go down or stay the same but went up) - not sure how to phrase that in terms of log reduction but guess it means there was a log increase?? - it is still in a positive territory for someone at 12 months, according to my doctor -- although he recommended re-doing the PCR to see if the finding reflects a lab error. My question is - if the results are accurate -- what could that mean?? I take gleevec 400 mg and never miss a dose - so could this be a sign of other mutations involved -- is it common for numbers to fluctuate?
Thank you for your help.